PAW Hepatoadvanced is a chewable fish-flavoured tablet supplement for medium and large dogs — those 15kg and over — developed by PAW by Blackmores to support liver function. It's used in dogs managing chronic liver disease, acute liver toxicity, or the hepatic burden that can accompany long-term medication use.

Each tablet combines S-adenosylmethionine (SAMe), Silybin, and Vitamin E. SAMe supports the liver's production of glutathione, a key antioxidant central to detoxification. Silybin — derived from milk thistle — provides hepatoprotective activity, while Vitamin E rounds out the antioxidant support. Together they address the functional demands of chronic liver disease management and medication-induced hepatic stress.

Hepatoadvanced is typically used alongside conventional veterinary treatment for liver conditions rather than as a standalone remedy. The fish flavour makes daily compliance straightforward for large dogs — a meaningful detail when supplementation is ongoing rather than a short course.