Frontline Plus for Extra Large Dogs 40–60kg is a 6-pack of monthly spot-on flea and tick treatment dosed for the largest weight tier. The larger pack provides six months of continuous protection against fleas, paralysis ticks, brown dog ticks, and biting lice.

Each pipette delivers fipronil and S-methoprene at the dose calibrated for dogs in the 40–60kg range. Fipronil kills adult fleas and ticks on contact, while S-methoprene prevents flea eggs and larvae from maturing in the dog's environment. Applied to the back of the neck once a month for fleas; for paralysis tick areas, reapply every 2 weeks. Water-resistant once dry.

Giant-breed dogs need the right dose tier to maintain full coverage, and the 6-pack removes the need for frequent top-up purchases. Extra-large dogs also tend to have more coat to manage, making the spot-on format a simpler option than oral treatments for some households.