Frontline Plus is a spot-on flea and tick treatment for extra large dogs between 40 and 60kg. This six-pack delivers six monthly doses combining fipronil and (S)-methoprene to target both adult fleas and their immature life stages.

The two active ingredients work in parallel: fipronil kills adult fleas and ticks on contact, while (S)-methoprene disrupts flea eggs and larvae before they mature. This breaks the flea cycle rather than just reducing the visible population. Each dose is applied to the skin at the back of the neck and remains effective for one month. The extra large formulation is dosed specifically for the 40–60kg weight bracket.

The six-pack suits owners who prefer to stay ahead of flea season rather than sourcing individual doses month to month. Frontline Plus is one of the most established spot-on treatments used in Australia, with a well-documented track record across both fleas and ticks.